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Because TrkB knockout mice die as neonates, we engineered a transgenic mouse that expressed a dominant negative form of TrkB (dnTrkB) in a conditional and reversible manner.
To confirm these findings, Silver et al. used a reporter mouse that expressed ST2 labeled with green fluorescent protein (GFP), they found that upon stimulation with IL-12, IL-18, and IL-33, the number of IL-18Rα+ ILcellslls increased, and 50% of these cells expressed ST2-GFP.
In order to monitor SEA-DR1 interactions on cell membranes, we utilized a transgenic mouse that expressed the human MHC class II molecule HLA-DR1 as the only MHC class II molecule on the surface of its antigen presenting cells (DR1 tg mice, [32] and Dalai, S and S. Sadegh-Nasseri, unpublished data).
We chose to study a transgenic mouse that expressed a temporally controlled, stabilised β-catenin protein.
We made a transgenic mouse that expressed an N-terminally truncated form of Gli2 under the control of the lck promoter.
In 2002, Donehower and colleagues serendipitously studied the effects of increased p53 activity, when, due to a targeting event gone wrong, they created a mouse that expressed a truncated version of p53 (Tyner et al., 2002).
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NEXT STEPS: Researchers will try to better understand the RNA gene's role in brain development and cognition by creating a mouse that expresses the human form of the gene.
It is based on a transgenic mouse that expresses human CD20 (hCD20) under its own hCD20 promoter [6].
A transgenic mouse that expresses HTLV-1 Tax also develops T-cell leukemia/lymphoma and an inflammatory arthropathy that resembles rheumatoid arthritis.
The investigators gave injections of minocycline to 6-week old mice that expressed the symptoms of HD.
They then crossed the founder mouse with mice that expressed the Cas9 protein, producing zygotes whose hgRNA sequences started being cut and mutated shortly after fertilization.
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