Domestication by hundreds of generations of inbreeding has resulted in strains of laboratory mouse that display constrained innate behavioural responses when compared to wild (or recently wild-derived) relatives [ 52- 54].
Four founder males derived from the G1 clone each gave rise to mice that displayed an enlarged anterior chamber.
We have recently discovered however, that the K14-agouti transgene was co-injected with the MMTV-Cre DNA to facilitate the identification of mice that displayed germ line integration of the transgene, since these mice display light yellow fur color in the background of black fur (L. Hennighausen, personal communication).
In this study, we generated STZ-induced diabetic mice that displayed depressive phenotypes.
In contrast to wild-type mice that displayed macrophage, lymphocyte, and neutrophil recruitment followed by emphysema, CD8-/ mice had a blunted inflammatory response and did not develop emphysema.
The first evidence of a role of angiopoietin-2 in lymphangiogenesis was suggested by the angiopoietin-2-null mice that displayed disorganized and hypoplastic lymphatic capillaries [ 148].
Together with a series of related senescence-accelerated mice, the SAMP strains were established 40 years ago by conventional inbreeding of AKR/J-derived mice that displayed features of accelerated aging such as hair loss, reduced activity, shortened life expectancy, lordokyphosis (increased curvature of the spine), and periophthalmic problems [ 40].
They began with mice that display some of symptoms of Alzheimer's.
To test the excitation-inhibition balance hypothesis, the Stanford scientists employed a strain of mice that display classic symptoms of autism.
However, being distinct but contiguous regions we are aware of no a priori size relationship that must exist, and indeed a recent study has shown size differences in the minor satellite region of chromosomes from different mice that display the same sized major satellite region5.
