The work by Ryu et al. (2006) using SSC transplantation into a heterologous recipient environment (young or aged, busulfan-treated mouse testis) suggests that SSCs are potentially immortal, since the self-renewal capability of SSCs from an older donor was maintained in a young environment, while aged testes failed to support normal colony formation [ 44].
In mice with the Sacytm1Lex locus, lacZ expression was only detected in testis, suggesting that at least the promoter and exon 1 are specific to male germ cells.
By contrast, the lack of ChoKα results in embryonic lethality, and ChoKα+/− heterozygous mice display an accumulation of Cho and a reduction in PCho in liver and testis, suggesting that there is no ChoKβ compensation for PC biosynthesis in vivo.
However, CYP1A was not significantly induced in TCDD-exposed testis, suggesting that gene expression and histopathological responses observed in the testis at 48 h may be CYP1A-independent.
Nuclear localization of TCF21 was observed in the Sertoli cell in testis of the E13 and E14 testis, whereas it appeared in the interstitial cells in E16 testis suggesting it has multiple functions during testis differentiation.
This organization is observed uniformly throughout the entire 1.7 m tubule length that constitutes a single mouse testis (Russell et al., 1990), suggesting that seminiferous tubules lack a discrete anatomically defined niche.
Initially, piRNAs from adult mouse testis were found to contain less RTE sequence than would be expected from the genomic content of RTEs, suggesting that piRNAs were not specifically targeting RTEs [ 27, 28].
Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis.
Guan, K. et al. Pluripotency of spermatogonial stem cells from adult mouse testis.
Kim, E. et al. Identification of novel retromer complexes in the mouse testis.
