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The primary benefit of the model mouse system is that it allows us to study abnormality at the molecular level.
A defining feature of ground state pluripotency in the mouse system is that transcriptional regulators such as Nanog are expressed homogeneously (Wray et al., 2010).
An important molecular signature of naive pluripotency in the mouse system is the use of the distal enhancer (DE) of OCT4.
The main interest of the mouse system is to exploit the recent generation of transgenic mice and to study the consequence of deficiencies, mutations and conditional expression of gene products.
It has been shown that CXCR2, the chemokine receptor for CXCL1 (keratinocyte-derived chemokine, KC) and CXCL2/3 (macrophage inflammatory protein 2, MIP-2) in the mouse system, is involved in the regulation of vascular permeability and in neutrophil recruitment in different models of ALI [ 5- 7].
Although recent reports show that there are a number of human DC subsets capable of cross-presentation 35, 36 and direct comparison with the mouse system is difficult, the results illustrate the efficiency of DNGR-1 targeting as some previous studies using the same peptide and monocyte-derived DCs as stimulators failed to show recognition of tumour cell expressing endogenous MUC1 26.
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Thus, the lessons learned in the mouse system are likely to be applicable for understanding human aging and for developing novel anti-aging clinical strategies.
Hybrid xenograft mouse systems were chosen for investigation because they offered the most accurate representation of melanoma in human skin.
Using two well-known developmental toxicants [5-fluorouracil (5-FU) and ATRA], cytotoxic effects similar to those previously observed in mouse systems were observed in hESCs and human fibroblasts.
Envision+anti-mouse system was used for antigen-antibody detection.
It is palpable to understand that the immune system-associated genes are significantly upregulated at the late stages of mouse development when the mouse immune system is developed and begins to function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com