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The gpt delta transgenic mouse system, established in the laboratory of one of the coauthors provides a unique opportunity to assess the in vivo mutagenic potential of mineral fibers (Masumura et al. 2003; Nohmi and Masumura 2004, 2005).
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In addition, mouse model systems established using cancer cell lines confirmed the results obtained in in vitro assays and further established the role of miR34a as a tumour suppressor (Pramanik et al, 2011b; Kasinski and Slack, 2012; Kumar et al, 2012; Li et al, 2012).
Our findings extend the reported findings from the human system to the mouse system, and establish further concordance between ANCD4 and NCD4lo T cells and confirm that this axis may indeed be specifically affected during cellular aging.
In general, the mice receiving DSS had a clinical disease activity score of 9.4±1.1 in 5-day group based on the score system established previously [17].
It's an amazing cat and mouse system.
e2f1−/− mouse system.
The majority of mouse specific systems were established in collagen-induced models while models of instability-induced or bacterial arthritis models were only rarely used.
Because its symptoms resemble human typhoid fever caused by the S. enterica serovar Typhi, which only infects man, STM-mediated systemic infection in mice represents an established model system to investigate the pathogenesis and immunology of typhoid fever in humans [ 6, 7].
Here we evaluate the immunogenicity of C-S8p260, finst in a mouse model system to establish a proof of principle, and second, in swine, the natural host of FMDV C-S8c1.
In the present report, we have used the Vβ12-tg mouse to establish a system where it is possible to track T cells specific for galactosylated CII peptide.
To quantify the age at onset and frequency of hind-limb immobility attacks in mice, we established a scoring system in which all mice were tested once a week from weaning until 60 weeks of age.
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