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Mice infected with these mutants had an increase in time of survival after induction of neutropenia but variable, strain-dependent effects on overall mouse survival with different T3SS mutants.
Administration of Cimetidine prolonged mouse survival with a median survival time of 22 days for treated mice as compared to a survival time of 15.5 days for untreated ones (n = 8, p = 0.03) (Figure 7B).
37 In primary effusion lymphoma, rapamycin reduced the accumulation of ascites and extended mouse survival, with significant reduction in levels of circulating VEGF.
In the murine xenograft studies, survival of mice between the two treatment groups was determined by the Kaplan Meier test using the log-rank analyses to compare the mean overall mouse survival with 95% confidence intervals.
We have previously reported therapeutic activity for KAF156 in a malaria mouse model (14), using the P. berghei GFP expressing ANKA-strain (25) and, for reasons that remain unclear, we did not observe a dose-dependent increase in mouse survival with this parasite strain.
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Considering that in any case AdNK4 plus DAS prolonged mice survival, with respect to AdNK4 alone, notwithstanding similar bioluminescence signals at 30 days, in the following experiments we tried to give an explanation examining cellular processes possibly affected by AdNK4 plus DAS versus the single treatments.
The effect of SU6656 treatment on mouse survival is consistent with its effect on dissemination.
Furthermore, Ad.IL3-MnSOD significantly prolonged mouse survival as compared with Ad.sp-E1A.
Mouse survival measurements were performed with 6-week old C57LB/6 mice.
The LogRank test was used to compare the mouse survival rate after challenge with T. cruzi.
We also report the association of lung BALT structures with mouse survival following vaccination and subsequent respiratory infection.
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