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Mouse survival was monitored on the daily basis.
Therapeutic gene transfer to the liver rescued glycogen accumulation in muscle and the central nervous system, and ameliorated cardiac hypertrophy as well as muscle and respiratory dysfunction in the Gaa-/ mice; mouse survival was also increased.
Mouse survival was monitored for 4 days.
After the injection, mouse survival was monitored.
Mouse survival was analyzed by the Kaplan-meier curve and the Log-Rank test.
The effect of the inhibitor on mouse survival was also tested.
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To determine antitumor activity, mice were implanted with MC38-CEA-2 cells and immunized with VRP-CEA with and without VRP-IL-12, and tumor growth and mouse survival were measured.
In addition, differences in mouse survival were assessed on each day using Fisher's exact test.
The effect of SU6656 treatment on mouse survival is consistent with its effect on dissemination.
Statistics for mouse survival were performed using the Kaplan Meier log rank survival test and considered different if p<0.05.
Figure 1C and 1D show that MyD88−/− and TLR2−/− mice infected intradermally also demonstrate significantly reduced survival and increased mortality rates compared to B6 controls, indicating that mouse survival is dependent on TLR2 signaling regardless of the route of infection.
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