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Untreated, the average mouse survival time was only approximately 10 days.
The results showed that although SU6656 treatment did not prevent death, it prolonged mouse survival time (Fig. 6, F, p<0.05, compared with the control group).
Efficacy of the conjugate and free ADR were determined as a percent increase of mouse survival time as compared to mice given PBS as control.
Mouse survival time and tumour recurrence were measured.
While, knocking-down PP6c improved the effect of radiation treatment and increased the mouse survival time.
Although these mutants increased tumor metastasis, they do not shorten mouse survival time as compared with p53-null background.
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Mouse survival times were analyzed by the Mantel-Cox log-rank test.
Lag phases in tumor growth before and after treatment and final mouse survival times were recorded.
Furthermore, in in vivo experiments using a mouse model liver cancer, changes in tumor volume, tumor growth, and mean mouse survival times in response to treatment were assessed, after treatment with the two photosensitizer types.
With a dose of LAPA in PL-gel group only less than 5% of that in P-gel + L-oral group, PL-gel demonstrated significant tumor suppression similar to P-gel + L-oral group, and showed longer mice survival time.
Our results showed that the radiation treatment prolonged the mice survival time in all group.
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