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However, the mouse became the model of choice for researchers exploring the genetic underpinnings of addiction after the first mouse study was published demonstrating the capability of engineering the mouse genome through embryonic stem cell technology.
The studies, one on mice and one on people, have identified two hormones that seem to fine-tune the perception of sweetness, and thus regulate the intake of sugar independently of the previously known mechanism of satiation that is located in the brain.The mouse study was done by Steven Munger, a neurobiologist at the University of Maryland, and his colleagues.
The follow-up time in their mouse study was rather short especially for dosimetric and quantitative purposes.
Key rat tests were afflicted by disease in the animal colonies; a mouse study was several months too brief and did not expose animals during gestation.
Animal experiments were conducted in accordance with the Declaration of Helsinki and approved by National Authorities: One mouse study was approved by the Austrian regulatory authorities (MA58/000351/2009/13).
This mouse study was approved by the Albert Einstein College of Medicine animal use committee.
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The corresponding frequencies in the mouse study are also shown.
A detailed description of the GENDEP mouse study is found elsewhere [ 39, 40]).
What is new in the spiny mouse study is the fact that pregnant dams were fed Cr.
Owing to solubility limits, tumour boron concentrations in this mouse study were too low for effective application of BNCT.
Full details of the mouse study were approved by the Institutional Animal Care and Use Committee at the University of Yamanashi (Approval number: 19-92).
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