Our recent Rnd3 genetic mouse study demonstrated that Rnd3 is a novel mediator that inhibits Notch signaling by facilitating the ubiquitination of the Notch active isoform, NICD, in the mouse brain.
For example, a recent mouse study demonstrated that anti-α-gal antibodies induced by the presence of Escherichia coli O86:B7 in the gut are cytotoxic to α-gal-expressing Plasmodium sporozoites, and thus protect mice from mosquito-transmitted Plasmodium infection [ 25].
In sharp contrast, our in vivo mouse study demonstrates for the first time that Mst1 is crucial for cell survival rather than cell death in response to intracellular ROS, at least in naïve T cells, and it accomplishes this function by regulating FoxO proteins.
Epidemiological studies of MMA and DMA have been fewer, but mouse studies demonstrated that these compounds may be anorectic agents [ 13- 15].
In addition, several xenografts in NOD/SCID mouse studies demonstrated that LFM-A13 did not show notable levels of adverse effects in alone or in combination in-vivo.
Data from rat and mouse studies demonstrated an increased risk of C-cell carcinoma for liraglutide, although this has not been proven in humans [ 70].
Elegant mouse studies demonstrated that transfer of Th17 cells generated in the presence of IL-23, but not TGFβ, caused autoimmunity in mice (McGeachy et al., 2007; Ghoreschi et al., 2010).
Breast cancer cells with different levels of malignancy, according to in vitro and in vivo mouse studies, demonstrated invasive and metastatic properties within the embryonic zebrafish model that nicely correlated with their differential tumourigenicity in mouse models.
However, previous transgenic mouse studies demonstrated that the human TSPY promoter could be preferentially active in neurons of pre- and postnatal brains, suggesting a possible function of this Y chromosome gene in neural development [ 32].
For example, mouse studies demonstrated an inverse relationship between maternal alcohol dehydrogenase activity and maternal blood alcohol levels and consequent fetal abnormalities, but suggested that other inherited factors from both the mother and the fetus were also important [ 19, 21- 23].
Mouse studies demonstrate that the particles are not only harmless, but that they soak up cancer drugs like sponges.
