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But he, too, questioned whether the mouse studies were pertinent for humans.
The in vivo mouse studies were carried out by Eurofins Panlabs.
Mouse studies were performed in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health.
In vivo mouse studies were done firstly to determine the optimum magnetic vector composition, and then to observe immune responses elicited when magnetic vectors were introduced via different administration routes.
The mouse studies were performed using a commercially available preclinical PET/MRI system (nanoScan®, MEDISO Budapest, Hungary).
Mouse studies were performed under IACUC approvals from MSSM and BIMR.
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That is partly because the tumors used in mouse studies are somewhat artificial, often injected into mice whose immune systems have first been disabled.
Dr. Koh explained that even though the mouse studies are provocative, they are not proof that sunscreens are useless in preventing melanoma in humans.
Previous mouse studies are ex vivo autoradiography works [7 9], in which follow-up of the same animals was not possible and test-retest measurement was disabled.
The low lung volumes associated with sedation (without ventilation) in mouse studies is also associated with an underestimation of FDG uptake within the lung.
The Marchuk lab's mouse studies are particularly interested in harnessing the power of mouse genetics to map novel genes that affect the severity and progression of disease in mouse models of disease.
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