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"Based on the mouse studies, we had expected" that the supplement would have a positive impact.
In light of encouraging results in mouse studies, we are now testing this approach at Memorial Sloan Kettering in patients with chronic lymphocytic leukemia and acute lymphoblastic leukemia who are no longer responsive to chemotherapy.
In parallel with these mouse studies, we investigate the roles of mast cells in human health and disease by conducting studies of human mast cells, or by analyzing specimens derived from patients with asthma or other disorders in which mast cell have been implicated.
Using DNA microarrays and knock-out mouse studies, we showed that CCR5 plays a definitive role in the development of ovalbumin-induced allergic airway inflammatory disease.
In our previous mouse studies, we found that conditional knockout (cKO) of Rb in Sertoli cells caused progressive Sertoli cell dysfunction.
Before conducting in vivo mouse studies, we first determined the potential dose-dependent responses of Vpr-induced cell killing in both wild type (WT) and drug resistant (DOX-R) SK-N-SH neuroblastoma cells.
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In the mouse study, we demonstrated that citBiP-immunization could induce several ACPAs.
In a mouse study, we observed that immunization with citBiP induced ACPAs, including anti-CCP and anti-citrullinated fibrinogen antibodies.
On the basis of our mutant mouse study, we suggest that PCP pathway mutations should be sought when NTD and renal malformation co-exist.
In the co-clinical mouse study, we observed that nab-paclitaxel-treated animals have also a distorted collagen with low cellular content while gemcitabine-treated mice showed a marked increase in CAF.
In a previous in vivo mouse study, we found that hyperoxia increased high VT-induced lung neutrophil sequestration and increased MIP-2 production, which was, at least in part, dependent on the c-Jun N-terminal kinase and extracellular signal-regulated kinase pathways [ 12].
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