Our recent mouse KO studies (see below) revealed that the in vivo functions of Rbx1 and Sag are non-redundant during embryonic development with each protein potentially targeting different sets of substrates.
Although sarcolipin has been detected in mouse skeletal muscle in other studies (see [5,8,9]), the levels of sarcolipin have not been quantified.
47 The impact of genomic imprinting (the parental origin of specific effects of inherited alleles) on disease has been well studied in mouse models and some human studies (see Peters 48 for a review of evidence on genomic imprinting); evidence from these studies shows that parent-specific imprinted genes have a significant range of effects on biological processes extending into adulthood.
You cite sunflower and mouse studies, but also see Harushima et al. 2001 (rice), Moyle and Graham 2006 (tomato), Ross et al. 2011 (C. briggsae ), Gagnaire et al. 2012 (whitefish), Corbett-Detig et al. 2013 (D. melanogaster ).
You cite sunflower and mouse studies, but also see Harushima et al. 2001 (rice), Moyle and Graham 2006 (tomato), Ross et al. 2011 (C. briggsae), Gagnaire et al. 2012 (whitefish), Corbett-Detig et al. 2013 (D. melanogaster). 1) Confirmation of LD not being driven by physical linkage.
Plots depict alternative network construction methods (color coded, see Figure 5 figure supplement 2 ), indicating that GEMOT has an advantage over existing methods with noise levels ranging between 0.25 and 1, which is the relevant range for the mouse data in this study (see Figure 5 figure supplement 3 ).
The profile is a consistent indicator of pluripotency; 90% of the 1,000 closest pathprint-matched samples in GEO are ESCs and induced pluripotent stem cells (iPSCs) from 140 different human and mouse studies and 13 platforms (see Additional file 8; see Additional file 9).
Although the assumption that all TFs bind to DNA in double-strand manner works well in yeast [11], it may not be sufficient in higher organisms, such as mouse, as shown in this study (see, e.g., Figure 3(a)).
For references for all of the mouse lines used in this study, see the Supplementary material online, Methods.
Interestingly, a functional copy of a Vent gene has been lost from the mouse genome; only a fragment of the Vent-type homeodomain in the mouse genome can be identified (this study; see discussion).
