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We eventually plan to merge both human and mouse studies in humanized, gnotobiotic animals that are colonized with human microbiota, taking advantage of the newly established gnotobiotic facility at Yale.
Thus, to mimic the mouse studies in humans, you may need to run a 5 – 8 year study in thousands of patients and measure clinical outcomes.
IARC had to cherry-pick the results from two mouse studies in order to make its tortured case that the animal evidence supported a conclusion of carcinogenicity.
This has also been reported in mouse studies, in which ablating hippocampal neurogenesis did not produce behavioral abnormalities at baseline (in the absence of treatment), but abolished the therapeutic effects of antidepressant treatment in the setting of stressful conditions [18], [19].
Again, this is in line with mouse studies in which remethylation occurs in male germ cells during late gestation [ 5].
This dichotomy may overemphasize the role of IL-6 (from mouse studies) in human Th17-mediated osteoclast formation.
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The R2 compound was chemically synthesized for biochemical analyses in vitro and for mice studies in vivo.
In mouse studies differences in diet or mouse strains have been used to identify distinct expression profiles [ 14- 16].
Summary data that includes and illustrates results from all mice studied in shown in Figure 5B.
There were 12 mice studied in these three experimental groups and 8 mice in the two control groups.
All mouse studies were performed in accordance with NIH and Institutional Animal Care and Use Committee guidelines.
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