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Other mouse strains, such as rocker, leaner, and engineered strains, display a range of phenotypes, from mild, paroxysmal motor dysfunction to chronic dystonia, similar to the range of neurological problems exhibited by EA2 patients.
Inbred mouse strains such as C57BL/6J (B6) and DBA/2J (D2) and related strains have been used extensively to help identify genetic controls for a number of ethanol-related behaviors, including acute intoxication and sensitivity to repeated exposures.
Some inbred laboratory mouse strains, such as BALB/c and C57BL/6, also have different proteins expressed in their urine.
In this respect, established mouse strains, such as C57BL/6, have long hypervariable telomeric DNA lengths if compared with strains recently derived from wild mice ([48]).
Our results demonstrate that the opposite is true for 'permissive' mouse strains such as the 129Sv, C57B/L6 and 129/BL6 F1 genetic backgrounds used in this study.
Fourthly, most SNPs were discovered by comparison of the genomes of several classical inbred laboratory mouse strains (such as C57BL/6J, DBA/2J, A/J and 129S1/SvImJ).
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These studies suggest that Leishmania amastigotes undergo progressive and continuous replication in susceptible mice strains (such as BALB/c), leading to systemic infection and death.
In contrast, while parasite numbers increase in resistant mice strains (such as C57BL/6) during early stages of infection, numbers subsequently plateau and eventually are reduced to a low level as a protective host immune response develops.
Although some mouse strains are closely related, such as the classical laboratory inbred strains C57BL/6J and A/J, wild-derived strains such as PWK/PhJ and CAST/EiJ are more genetically variable and, in fact, represent the M. musculus castaneus and M. musculus musculus subspecies, respectively (Collaborative Cross Consortium 2012).
The ubiquitous expression of truncated p53 protein isoforms, results in "premature ageing" of laboratory mouse strains engineered for expressing such isoforms.
Two such mouse strains can have up to 20 million differences between them.
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