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This requirement was elegantly illustrated in a landmark study by Ubeda et al. showing that differences in the composition of the microbiota observed in TLR-deficient mouse strains reflected long-term divergence of the microbiota when the different mouse strains are housed in isolation from each other rather than defective innate immunity.
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Under the first hypothesis, the substantial DNA sequence divergence between mouse strains would be reflected in many expression differences.
We observed significant differences in clamp data from the mouse strains fed either diet, reflecting greater insulin sensitivity in the OPN KO mice (Figure 2A C).
This difference in the rate of reduction in β-gal activity between the two mouse strains is considered to reflect immune rejection of the hMSCs.
Willing et al. used 16S RNA analysis to show that within 4 5 days of fecal transplantation, mice had an altered microbiota composed of microbial families from both the donor and recipient mouse strains, with ratios that strongly reflected the donor strain.
The observed separation of the mouse strains in PCA, PLS-DA and GeneRaVE, reflects the observed phenotype and gene expression, with the 569 mutant locating between the wild-type and the 391 mutant.
Therefore, the large genetic diversity of laboratory mouse strains leads to more transcriptional diversity than is reflected in the reference annotation.
Here we explore whether behavioral differences between the mouse strains and functional specificity of the two brain regions are reflected in differential gene expression profiles.
The observed increase in weight reflected an increased fat deposition for all mutant mouse strains.
Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity.
Their study using various mouse strains demonstrated that the course of TB was different and dependent on the mouse strain used, which is also reflected in their IGRA results [ 17].
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