Many genetically modified mouse strains are now available on a C57BL/6 (H-2b) background, a strain that is relatively resistant to collagen-induced arthritis.
No compensatory pathway has been identified in this mouse strain untill now.
KO mouse strains from the IMPC are now becoming available for lethal screening, and national efforts need to be coordinated as soon as possible, in order to take advantage of the limited time window during which such a programme is economically feasible.
So, we're now infecting more susceptible mouse strains to see if we can find blood signatures and pathology in mice that resemble the human situation more closely.
With the recent progress in gene technology, represented by various knockout or transgenic mouse strains, the expression of specific genes can now be easily modified.
We have now examined this using two mouse strains that differ markedly in susceptibility to atherosclerosis.
Over 450 inbred mouse strains have been described and developed up until now, providing plentiful phenotypes and genomic backgrounds for genetic studies.
Thus, it is now becoming feasible to map trait variation in inbred mouse strains by testing association to loci of inferred ancestry [24], [43], [44].
Snell [ 13] continued the analysis of histocompatibility by breeding mouse strains that differed from one another at single histocompatibility loci, his so-called congenic strains (although we now know that each MHC is a composite of several closely linked genes).
Thus, we now determined the multiple QTLs that were not identified in previous studies using the established laboratory mouse strains.
