Several mouse strains, including tottering mice, carry loss-of-function mutations in the Cacna1a gene and have been used to investigate the pathomechanisms of EA2.
Genetically engineered mice are usually produced on a mixed genetic background and can be derived from several mouse strains including 129SvJ, C57BL6, and BALB/c.
In additional experiments, 26 nuclear transfer embryonic stem cell lines were established from 108 cloned blastocysts derived from four mouse strains including inbreds and F1 hybrids with relatively high success rates.
We also discuss hematopoietic PRC1 gain- and loss-of-function mouse strains, including those that model leukemic and lymphoma diseases, in the belief that these genetic analyses provide the ultimate test for molecular mechanisms driving normal hematopoiesis and hematological malignancies.
RESGRO™ is an FBS-based medium conditioned by rabbit fibroblast cells transduced with genomic rabbit LIF and shown to be efficient for derivation and generation of germline chimeras using several mouse strains including B6 [17].
In the present study, we selected 33 inbred laboratory mouse strains, including 31 classical inbred strains and 2 wild-derived strains, based on the Mouse Phenome Database priority list and the availability of single nucleotide polymorphism (SNP) data.
These results suggest that DBA mice, and particularly DBA males, exhibit resistance to the elevated expression of leukocyte-associated transcripts with HF diet that is characteristic of other mouse strains included in our analysis.
Similar to ApoE−/− mice, nearly identical data were reproduced in the Ldlr−/− mouse strain, including cold-induced WAT-to-BRITE transition, activation of BAT, adipocyte size changes and UCP1 upregulation, lipolysis, body weight and BMI decreases, cholesterol synthesis alterations of blood lipid profiles, plaque growth, and instability index.
The prevalence of MuLV envelope protein-positive antibody in NOD mice was around 46%, while the non-NOD mice strains including BALB/c, ICR, C57BL/6, and SJL/J mice did not produce this envelope protein-reactive antibody.
Similar to Ogg1 p.R304W, Mbd4 p.D129N was previously found in normal mice strains including 129P2/OlaHsd, 129S1/SvImJ, 129S5SvEvBrd, DBA/2J, LP/J, NOD/ShiLtJ, and NZO/HlLtJ [ 21].
Corroborating with that, Singh et al [37] reported that a peptide sequence as small as 12-mer long could prime for antibody, T cell proliferative as well as for DHT response in different mice strain, including Balb/c.
