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Our studies reveal that inbred mouse strains exhibit large differences in their host response to an infection with the H1N1 influenza A virus (PR8).
Animal studies using a single dosage of ethanol during pregnancy show that different mouse strains exhibit different severities of morphological and fetal weight deficits after alcohol exposure, which the authors attributed primarily to maternal genetic effects [8] [10].
In particular, these mouse strains exhibit variable levels of STAT5 signalling in response to GH stimulation (Figure 1) and show substantial alterations in hepatic gene expression, together with growth deficit and later onset obesity.
In rodent hippocampus, MAPK is essential for LTP formation, and several APP mutant mouse strains exhibit deficits in hippocampal LTP and hippocampus-dependent associative learning paradigms, including contextual fear conditioning and escape training in the Morris water maze [30], [61], [62].
The MRL- lpr and NZB × NZW mouse strains exhibit extremely high disease penetrance and early death.
C/EBPβ mutant mouse strains exhibit increased bone resorption and attenuated expression of MafB, a negative regulator of osteoclastogenesis.
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After feeding a HF diet regimen for 16 weeks, both mouse strains exhibited similar impairments of endothelium-dependent vasodilation in response to ACh.
However, these differences were strain dependent, with some mouse strains exhibiting greater risk in males.
As expected for nocturnal animals, all mouse strains exhibited the vast majority of their wheel-running activity during the dark phase.
In contrast to the previous report (Lapuente-Brun et al., 2013), the analyzed mouse strains exhibited similar oxygen consumption rates with complex I or complex II substrates under phosphorylating, nonphosphorylating, and uncoupled conditions.
Runx3Cre mice crossed onto the R26-stopFlox-LacZ or R26-stopFlox-tdTomato reporter mouse strains, exhibited the characteristic Runx3 expression pattern with no expression in the GIT, whereas, when crossed onto the general deleter strain Pgk-Cre, the R26-stopFlox-LacZ or R26-stopFlox-tdTomato displayed ubiquitous blue staining or red fluorescence, respectively, including strong staining in the GIT.
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