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The 11 inbred mouse strains did not differ significantly for BE or testosterone concentrations.
Nevertheless, AM from both mouse strains did not produce any G-CSF (data not shown) neither in response to bacteria, nor to LPS or flagellin.
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Although some rat strains show complete susceptibility to ADR, most mouse strains do not.
We conclude that the presence of the short COX7a2l isoform in the commonly used C57BL/6 mouse strains does not prevent their use in metabolism research.
MCMV-susceptible mouse strains do not have Ly49H but the extracellularly very similar ITIM-bearing Ly49I protein which has inhibitory killer cell receptor activity.
Although mice are commonly used as non-clinical efficacy models, most mouse strains do not develop lung pathology similar to human TB, leading to concerns that results of drug treatment in mice might not always predict results in humans.
show that the presence of the short COX7a2l isoform in the commonly used C57BL/6 mouse strains does not affect the supramolecular organization and function of the mitochondrial respiratory chain.
Also, with the discovery of this additional splice variant (CAST-SV3) in CAST/EiJ macrophages, it becomes apparent that the previous annotation of Nlrp1b SVs as "alleles" is misleading, since Nlrp1b "alleles" of different mouse strains do not share the same genomic location.
In line with the data produced by comparing inflammatory responses in MC3R-null vs. WT mice, administration of the MC3R selective agonist to the latter mouse strain did inhibit also chemokine generation in the mesenteric tissue.
The type of mouse strain did not have an effect on the rate of inflammation in female mice as there was no significant difference in the number of leukocytes between female Balb/C, female C57BL/6 or female DBA/2 mice (Fig. 3e, g).
Although total lung pathology scores were similar in rage −/− and Wt mice at later time points, the former mouse strain did show significantly smaller areas of confluent inflammatory infiltrates at 48 hours after infection (17 ± 5% of their lung surface versus 31 ± 2% in Wt mice, mean ± standard error of the mean, P <0.05, Additional file 1: Figure S1).
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