To ensure that the intrinsic differentiation profiles of NPCs from each mouse strain cells were similar, neurospheres were dissociated and cultured under differentiating conditions that promote the accumulation of both neurons and glia [49].
Based on the difference of the innate immunity between two mouse strains, NK cell activities of orthotopic GBM xenograft models based on BALB/c-nude mice were inhibited.
We have developed computational methods (Cell Line Authentication by SNP Profiling, CLASP) for cell line authentication and copy number analysis based on a cost-efficient SNP array, and we provide a reference database of commonly used mouse strains and cell lines.
103 In addition to modulation of superoxide production of innate immune cells within the ALR mouse strain, CD4+ T cells may also play an important role in T1D resistance by generating shifts in oxidative status.
We used expression data from four eQTL studies in four different tissues in recombinant inbred BXD mouse strains: regulatory T-cell, lung, hematopoietic stem cells [ 28], and hippocampus [ 29].
Atlases of mouse development, gene expression atlases, transcriptome databases, and repositories of genetically engineered mouse strains and ES cells are discussed.
Because of the genetic homogeneity of inbred mouse strains, transplantation of cells from one mouse to another of the same strain is feasible.
In most mouse strains, primordial germ cells arrive at the genital ridge at 10 dpc, embark on a special program of division to form cysts at 10.5 dpc, start meiosis at 13.5 dpc through the stages of leptotene and zygotene, and then enter the pachytene stage at 15.5 dpc [15].
The mouse data sets include gene expression data from four tissues of recombinant inbred (RI BXDD mouse strains: regulatory T-cell (H. Chen, RA, and KS, unpublished data), lung (RA, L. Lu, R. Williams, and KS, unpublished data), hematopoietic stem cells [ 28], and hippocampus [ 29].
However, GI-101A tumor growth analysis upon VACV-infection in either immunosuppressed nude mice (MHCII+-cell depleted) or in immune-deficient mouse strains (T-, B-, NK-cell-deficient) revealed that neither MHCII-positive immune cells nor T-, B-, or NK cells contributed significantly to VACV-mediated tumor regression.
