It has been shown that certain mouse strains are the most sensitive animals for immune modulatory effects of PFOA and PFOS.
Inbred mouse strains are the genetic equivalent of identical twins, and they can serve as organ donors for each other without any immune suppression.
One must keep in mind that commercially available rat and mouse strains are inbred to some extent, even if they are described as outbred, and that genetic drift occurs over time even within inbred strains [8, 9].
Inbred mouse strains are used in forward-genetic experiments, designed to uncover genes contributing to their highly distinct neurophenotypes and multiple reports of variations in mutant phenotypes due to genetic background differences in reverse-genetic approaches have been published.
Several spontaneous and engineered alleles at the mouse dysferlin locus have been isolated and these dysferlin-deficient mouse strains are providing valuable insights into the role dysferlin plays in skeletal muscle physiology, heart function, and the regulation of the innate immune system.
Different mouse strains are used for different purposes.
The genetic variations between the two parental mouse strains are expected to affect all four experimental genotypes identically.
The inbred mouse strains are genetically identical within a strain largely as a result of breeding to homozygosity.
The R6/2 and YAC128 mouse strains are well characterized animal models mimicking many histopathological aspects of HD.
Distinct boundaries between clonal contributions from the two different mouse strains are visible for intestine, liver and lung (Figure 7A-D).
Secondly, Cre transgenic mouse strains are mostly generated by random integration of a DNA construct comprising promoter and Cre cDNA into the host DNA.
