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The C57BL6/J TH heterozygote mouse strain was kindly provided by R. D. Palmiter (University of Washington, Seattle, WA, USA) [ 26], and was backcrossed with wild-type CD1 mice for up to ten generations (for further details see the ESM Methods).
In all of them, the mouse strain was resistant to the formation of metastases.
Recently, a mouse strain was genetically engineered to knockdown the expression of Cox-2 [32].
The FVB inbred mouse strain was used because of its known suitability for transgenic experimentation and genetic analysis [14].
The NOK mouse strain was established by backcrossing JAK3−/− mice with the NOD.Cg-Prkdcscid strain for 10 generations.
CCE, an ES cell derived from 129/Sv mouse strain, was obtained from StemCell Technologies, Inc. with permission from Drs. Robertson and Keller (Vancouver, Canada) [17].
An inbred mouse strain was selected in order to control for genetic and environmental variables that could confound the interpretation of aging phenotypes.
The pedigreed congenic C57BL/6 Naglu-deficient mouse strain was acquired from The Jackson Laboratories [20], and was maintained and expanded by strict sibling mating.
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Mouse strain is called "Doogie".
One condition is that the transgenic mouse strain is recombinase-perfect.
The DBA/1 mouse strain is particularly sensitive to experimental immune-mediated nephritis.
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