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The APPPS1-21 moustrainain therefore appears to be a useful model for the study of APP and β-amyloid overexpression-related dysfunctions in synaptic activity and cognitive performance in the brain that is found in AD.
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This mouse strain is therefore used for most of the aging and spontaneous DNA repair studies.
This correspondence serves as a very important reminder that the genetic background on which you are studying your ciliopathy phenotype can result in different phenotypes dependent on the mouse strain and therefore needs to be considered in interpreting one's results.
Comparison of gene expression between the mouse strains could therefore give a clue as to which metabolic pathways might be responsible for the different phenotypes.
These two mouse strains are therefore very valuable new tools for beta cell research.
The embryonic lethality observed in Rad51 null mice [ 50] and many Brca1 and Brca2 mutant mouse strains may therefore be due to a failure of DNA replication.
It is especially important to note that Shifman et al. (2006) find these to be recent polymorphisms, not segregating among other inbred mouse strains, and therefore just an indicator of the potential recent mutation rate of 0.39% among polymorphic SNPs.
Data have been obtained in a commercially available mouse strain and can therefore easily be reproduced.
Here we emphasize the importance of accurate dose selection in rodent anxiety paradigms for concluding whether the mouse strain used is "sensitive" and therefore appropriate for studying anxiety in selected behavioral tests.
A reporter mouse strain with inducible expression would therefore be useful for identifying circuits involved in short and long term plasticity after stimulant and antipsychotic exposure but also with striatal-based learning paradigms.
The repertoire of functional VRs with which different mouse strains perceive stimuli therefore varies significantly.
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