Axenic embryo transfer into germ-free pseudopregnant recipient females allows for the efficient re-derivation of any genetically modified (Tg, KO, KI, reporter, fate-map) mouse strain from any hygiene status to germ-free status.
Since the xenograft models utilize immune deficient mouse strains to avoid graft rejection, immunologic microenvironments of transplanted GBM cells can be specifically modified by choosing a recipient mouse strain with defined immune deficiency status.
The transgenerational epigenetic inheritance of metastable epialleles was first demonstrated in a mouse strain, in which the methylation status of the Axin (Fu) allele, which is linked to the shape of the tail in the mature sperm, reflects the methylation status in the somatic tissue.
Different studies used different mouse strains, testing imprinting status in different tissues and developmental time points, and none of the studies published to date has employed a truly transcriptome-wide screen for imprinting.
LDV establishes chronic infections regardless of mouse strain, age, sex or immune-status [5], [8], [9], [10].
These findings suggest that PC antimicrobial function is independent of Nod2 status in this mouse strain.
Thus particle treatment was a within-subject (single measure) factor, while animal model (mouse strain) as well as allergy and COPD status was a between-animal factor.
An explanation for this enigmatic finding in an inbred mouse strain is not obvious, but differences in social status and related elevated stress levels might play a role [ 2].
To dissect VNO function in controlling female reproductive and neuroendocrine status, we have developed a mutant mouse strain harboring a conditional, olfactory marker protein (OMP) and Cre-mediated ablation of Gαo [ 41].
It is intended to use this detailed flux and pool model as basis for the study of the iron status of targeted genetic variants of the C57BL6 mouse strain.
