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Taken together, these data are consistent with the disruption of collagen X function in hypertrophic cartilage, and not mouse strain specific modifiers, as being responsible for an altered marrow environment and the peripheral lymphatic alterations changes observed in the collagen X Tg and KO mice.
Previous studies have demonstrated that chemically induced plasmacytoma are mouse strain specific.
Mouse strain specific variations of TRP channel expression indicate that genetic background or physiological requirements considerably influence expression levels.
Recent studies have described mouse strain specific gene expression profiles in the whole brain as well as in the specific regions, like the hippocampus, cerebellum, cortex or amygdala [ 20, 21, 28, 35, 36].
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These tissue injuries also were observed following the injection in C57BL/6 mice (data not shown), demonstrating that the toxicity was not mouse strain-specific.
Upon either maternal or paternal inheritance of the knockout, mice are characterized by a lethal phenotype that is mouse strain-specific.
The search of genes within QTLs has recently benefited from the advances in the mammalian genome research, particularly with regard to mouse strain-specific sequence databases allowing in silico discovery of gene-coding and gene-regulatory variants (3).
Recent studies demonstrating mouse strain-specific DNA methylation patterns [39], and at least two cases of allele-specific expression associated with specific SNPs in human [20] provide precedents for this idea.
Similarly, the well-documented mouse strain-specific hepatotoxicity and tumoricidial activity of MD5-1 was completely abrogated in Fc γRII mice.
In this study, we obtained mouse strain-specific rDNA sequence and observed that both sense and antisense nc-rRNAs were extensively expressed in corresponding A5 and E9 mouse lung cells, commonly used cancer models.
Sandberg et al in 2000 demonstrated mouse strain-specific differences in response to pentylenetetrazole kindling; however, this study focused on the changes invoked early in the response to a single seizure and gives limited insight into the actual process of epileptogenesis.
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