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This first large-scale genetic analysis of the outbred CD-1 mouse strain provides important considerations for the design and analysis of genetic studies in CD-1 mice.
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To understand such genotype-by-environment interactions, the diversity of existing mouse strains provides a valuable research tool [49].
This approach that exploits highly diverse mouse strains provides an efficient and effective translational bridge to study the etiology of human developmental disorders, such as autism and schizophrenia.
In the case of mutations such as those in Cep290 which do have pleiotropic effects, the difference between the outcomes in different mouse strains provides an opportunity to study how genetic variability affects the disease phenotype.
Improved transgenic mouse strains provide a powerful technology platform for creating human therapeutics in the future.
Also, the accumulating reports on hair phenotypes of mouse strains provide important pointers to better understand the molecular mechanisms underlying human hair growth disorders.
Novel transgenic mouse strains provide a powerful technology platform for creating fully human monoclonal antibodies as therapeutics; ten such antibodies have entered clinical trials since 1998 and more are in preclinical testing.
QTL analyses of crosses between other susceptible and resistant mouse strains provide additional evidence for the importance of multiple genes in P. berghei infection [15], [16], [17], [18].
A recent study, in fact, evaluated 42 inbred mouse strains provided an atherogenic diet for 18 weeks, and showed that DBA mice gained more body weight than any other strain [53], [54].
Highly fecund mouse strains provide an ideal model to understand the factors affecting maternal performance.
Both mouse strains provide adequate models for the study of perinatal exposure to xenoestrogens.
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