For the kinetic modelling study, we used the previously described RenTGF-β1 transgenic (Tg) mouse strain expressing mutated porcine TGF-β1 under control of the Ren-1c promotor [16].
In the present paper we generated a mouse strain expressing reduced β1 integrin levels to directly investigate the role of β1 integrin on skin formation and homeostasis, avoiding gross damages as seen in complete knockout animals.
Similarly, Hsiao et al. [29] reported that a transgenic mouse strain expressing a mutant amyloid precursor protein displayed impaired visuospatial learning and memory both in a Y-maze and in a Morris water maze at 9 10 months of age, but not at 3 months of age.
Limbic system-associated membrane protein 1b transcript was visualized by using a mouse strain expressing beta-galactosidase under the control of Lsamp 1b promoter.
In this work, we report successful generation of a new transgenic mouse strain expressing an enhanced form of firefly luciferase (Luc2) in a mammary tissue-specific manner.
For this, we utilized floxed PDGFR α mice 44 and a transgenic mouse strain expressing Cre recombinase under the control of the human glial fibrillary acidic protein promoter (GFAP-Cre).
Tumour cells were derived from a transgenic mouse strain expressing polyoma middle T (PyMT) antigen under the control of the mouse mammary tumour virus (MMTV) long-terminal repeat (Guy et al, 1992).
In view of the reported specificity problems associated with immunohistochemical detection of nAChR subunits [ 21], we utilized a reporter mouse strain expressing eGFP under the control of the chrna3 promoter coding for the essential α3-subunit [ 22].
Cbfb f/f mice were mated to either a mouse strain expressing Cre recombinase under control of the Wnt1 promoter (Danielian et al., 1998) to generate Wnt1-Cre; Cbfb f/f mice or to a mouse strain in which the Cre recombinase coding sequence was inserted into the Runx1 locus (Samokhvalov et al., 2007) to generate Runx1 CreER/+; Cbfb f/f mice.
In our project, we have generated a mouse strain expressing an enhanced firefly luciferase under a breast tissue-specific promoter and we present data documenting that it can be utilised as a new bioluminescent model for visualisation of mammary tumour development in transgenic mice.
