This mouse strain exhibits accumulation of surfactant in ATII cells, but shows normal secretion of surfactant phospholipids (Prueitt et al. 1978).
The nonobese diabetic (NOD) mouse strain exhibits immunological, histopathological and physiological characteristics of SS with focal mononuclear cell infiltration of the exocrine glands from approximately 8 weeks of age [ 7].
However, these differences were strain dependent, with some mouse strains exhibiting greater risk in males.
Although the number of LF present in the salivary and lacrimal glands does not often correlate directly with disease or its severity, SS patients and NOD-derived mouse strains exhibiting SS-like disease typically have lymphocytic infiltrates in their salivary glands.
After feeding a HF diet regimen for 16 weeks, both mouse strains exhibited similar impairments of endothelium-dependent vasodilation in response to ACh.
Our studies reveal that inbred mouse strains exhibit large differences in their host response to an infection with the H1N1 influenza A virus (PR8).
Animal studies using a single dosage of ethanol during pregnancy show that different mouse strains exhibit different severities of morphological and fetal weight deficits after alcohol exposure, which the authors attributed primarily to maternal genetic effects [8] [10].
In particular, these mouse strains exhibit variable levels of STAT5 signalling in response to GH stimulation (Figure 1) and show substantial alterations in hepatic gene expression, together with growth deficit and later onset obesity.
In rodent hippocampus, MAPK is essential for LTP formation, and several APP mutant mouse strains exhibit deficits in hippocampal LTP and hippocampus-dependent associative learning paradigms, including contextual fear conditioning and escape training in the Morris water maze [30], [61], [62].
The MRL- lpr and NZB × NZW mouse strains exhibit extremely high disease penetrance and early death.
