Exact(1)
Despite this, Serinc1 and Slc16a10, although not directly attributed in the literature with immune-related roles, have functions that could be postulated to affect immune cell responses and/or β-cell activity, which could be revealed in the context of the "sensitized" NOD genetic background (i.e., the NOD mouse strain enables detection of mutated genes that increase or decrease diabetes incidence).
Similar(59)
To determine the molecular function of the second step of hypusine modification in mammals, we generated a mouse strain enabling conditional knockout of Dohh (B6.Dohhtm1bal).
Determination of gene expression profiles between mouse strains enables flagging a modest number of differentially expressed genes, and is an efficient and sensible approach to circumvent tedious backcrossings, necessary to obtain isogenic animals.
In conclusion, the Rac-FRET mouse strain has enabled us to monitor the intricate and dynamic regulation of the small G protein Rac, an essential controller of distinct biological responses depending on timing, location, and signaling context.
The use of the Dbx1loxP-stop-loxP-DTA mice [16] and the appropriate Cre recombinase-expressing strain enables us to selectively eliminate specific dbx1-expressing populations.
Ironically, the strain enables him to relax.
Here, Timpson, Welch, and colleagues present a mouse strain, Rac-FRET, which enables the imaging and quantification of Rac activity in living tissue and primary cells.
The study of CII immunity in these two strains enables comparison between a classical mouse strain used in arthritis research and the recently developed transgenic strain that resembles the human situation more closely by expressing one of the most common HLA alleles in RA patients (HLA-DRB1*0401).
The ISH analysis was performed in the albino CD1 wild-type mouse strain in order to enable signal detection in the non-pigmented RPE.
Use of this mouse strain is advantageous because it also enables easy genetic manipulation of the microenvironment.
In this respect, Guedez and colleagues [ 40] found that genetic ablation of IFN-γ upregulates IL-1β and enables the elicitation of CIA in the nonsusceptible C57BL/6 mouse strain.
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