Aggregation turns embryonic mouse stem cells into mice.
Then, adipose tissue-derived mouse stem cells were differentiated to osteoblasts and adipocytes in inductive medium.
Consistently, dioxin exposure stimulated SERPINB2 expression in adipose-derived mouse stem cells (Fig. 3f).
However experiments in which dopamine neurons were created from mouse stem cells have not been successfully reproduced in humans.
Further, the orthologous murine signature correctly orders a time course of differentiating embryonic mouse stem cells.
Yang's group grew embryonic human kidney cells and embryonic mouse stem cells on silicon nanowires of varying diameters.
Using mouse stem cells arranged in a three dimensional culture, Dr Sasai's team mimicked the way pituitary glands develop in the embryo.
But Gage notes that immature neurons derived from mouse stem cells are more active than their mature counterparts, so an extended maturation period may actually be beneficial.
Scientists at the University of Pennsylvania transformed mouse stem cells into eggs in 2003, but did not use them to create mouse pups.
Yusa, K., Rad, R., Takeda, J. & Bradley, A. Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon.
After his team had shown the process turned embryonic mouse stem cells into brain stem cells, they repeated the experiment on human embryonic stem cells.
