Two exogenous transposon-transposase duos have proven to be powerful forward genetic mutagens in the mouse: Sleeping Beauty (SB), which was a non-functioning system that has been resurrected from salmonid fish, and PiggyBac, which is native to the cabbage looper moth (Bestor, 2005; Horie et al., 2010).
Aided by Lewin's shadowy watercolors of a forest at night, Bauer beautifully conjures the deepest part of winter, when bears and mice sleep but other creatures think they know how to bring the darkness to an end, like a moose who says, "I have antlers strong enough to scoop up the sun and bring it home" (the wind sighs, "Not you").
Moreover, in Prkg1SMr mice rebound sleep was apparent already after 2 h whereas in control mice, sleep time was initially reduced and only after 6 h did accumulated values exceed baseline (Fig. 2C).
In rats and some strains of mice, sleep suppressing effects of exogenous and endogenous female sex hormones were observed during dark periods when the animals are normally active.
In a study using optogenetics tools to disrupt sleep in mice, sleep fragmentation in itself can impair mouse performance in an object recognition task without affecting the overall amount or intensity of sleep (Rolls et al. 2011).
Similar consequences have been shown for mice sleep restricted for 6 h during the light phase or fed during the light phase only, with rhythms of metabolic genes or circadian genes in the liver being disturbed (Barclay et al., 2012; Damiola et al., 2000).
Later, two pet mice slept there, in a home made of fruit crates.
Wild descendants of domestic house cats, they prance brazenly around the island, catching rats and mice, sleeping under bushes, and generally ignoring any attempts to impose human will upon their lifestyle.
Colin has a factotum, Nicolas, a sort of Surrealist Jeeves, who serves pâté made out of eels that he finds in the plumbing, carries on conversations with mice, sleeps with teen-age girls, and is Alise's uncle.
