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Targeted gene disruption in the mouse shows that the Sonic hedgehog (Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial skeleton and the limbs.
The timeline of disease development in the Tsk2/+ mouse shows that fibrosis is progressive, with elastic fiber alterations and TGF-β1 over-production occurring at least two months before bona fide fibrosis, that is not dependent on ANA production.
The clustering of imprinted genes in the mouse shows that a series of genes play a role for the branching into embryonic and brain specific clusters at the 1st/2nd split.
However, a mouse ChIP-seq study that examined five transcription factors in 19 tissues and cell types of mouse shows that more than 70% of CNSs function in gene regulation (Shen et al. 2012).
BLAST analysis of MSHORT1 in the mouse shows that the repeat unit is unique for intron 10 of the Sfmbt2 gene and suggest a dual phase model for growth of the miRNA gene cluster: arrangment of 10 MSHORT1 units into MLONG1 and further duplication of 13 head-to-tail MLONG1 units in the center of the miRNA gene cluster.
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Studies in mice show that failed or sluggish autophagy causes neuron death.
Analysis of the blood and tumors from wounded mice showed that wound healing increases levels of cells called inflammatory monocytes, which differentiate into tumor-associated macrophages.
Studies with mice show that administration of ethanol to males alters the epigenetic signatures in the brains of their offspring.
In vivo studies in ICR and KKAy mice showed that administration of this compound resulted in decreased blood glucose in these mice after an oral glucose challenge.
Analyses of Asxl2−/− mice show that Asxl2 has an important role in animal survival and growth.
Studies in B-cell-deficient mice showed that protective immunity to Salmonella strongly depends on B cells [27].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com