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The mouse sequence shows additional glycosylation sites at position 270 and 776.
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The amino acid alignment between human and mouse sequences shows 55% identity.
Comparison of human and mouse sequences showed genetic identity >98% at the nucleotide level.
Finally, only 8/47 (17%, containing on average 2.3 expression domains in zebrafish and 2.3 in mouse) sequences showed fully consistent reporter expression patterns (Additional file 1).
Likewise, we found five SNPs in intron 1 of Papss2 between our strains of mice (Table 1); however, a BLAST comparison of the human and mouse gene sequence shows that none of the SNPs identified seem to match between species.
Note that the homologous regions based on the new measurement often comprise the best mouse BLAST hits and the best MegaBLAST hits when using the corresponding human regions as queries against the mouse sequences, which shows that the homologous regions are most likely orthologous [ 14].
Furthermore, sequence comparison between the human and mouse SPG4 genomic sequence shows a high degree of sequence conservation in the 5'-UTR of SPG4 and in a region of 400 base pairs (bp) upstream of the putative initiation of transcription, suggesting that this region may contain important regulatory elements.
Alignment of human and mouse HCN2 sequences shows that these residues are conserved among species and suggests that the regulation of channel activity by phosphorylation might also be conserved.
In addition, the comparison of human and mouse genome sequences showed that the segmental duplications are highly related to chromosomal breakpoints in the inversion areas [48].
However, new figure files are provided since some arrows and stars have been previously misplaced in figures three A (figure 1) and four (figure 2), and the former figure six (figure 3) showed the GPR50 mouse sequence instead of the human sequence as stated in the legend [ 1].
Similarly, 5%% of the rat sequence showed this high degree of sequence identity with the orthologous mouse sequence.
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CEO of Professional Science Editing for Scientists @ prosciediting.com