A recent study reported that alpha-like cells in mouse retina express melanopsin [38] and therefore we sought to determine if the alpha cells described in the current study that are afferent to the DRN were melanopsin cells.
Moreover, we found that when we transplanted the FACS purified iPSC derived photoreceptors, they were able to integrate into a normal mouse retina and express photoreceptor markers.
We report here that in the developing mouse retina p107 is expressed in embryonic retinal progenitor cells, and Rb is expressed in postnatal retinal progenitor cells.
In the mouse retina, Dscam is expressed in many, but not all neuronal subtypes.
Until now it is not clear, if the same connexins that have been identified in the mouse retina are also expressed in the human or at least primate retina.
Also, a recent study has shown that in the developing mouse retina, notch2 is expressed in progenitors and Müller glia (Zhu et al., 2013), an expression pattern that is reminiscent of that for mdka in the developing zebrafish.
Our own studies demonstrate that randomly selected proteins from within the MD quadruples and other ataxin-7 interactors are expressed in the mouse retina and some show altered expression in a mouse model of SCA7.
In the mouse retina, the expression of a surrogate marker suggests that HIF-2alpha is expressed by cells in the ganglion cell layer, inner nuclear layer and retinal pigment epithelium [45].
We demonstrate that both BACE1 and BACE2 are expressed in the normal mouse retina with BACE1 most highly expressed in the neural retina and BACE2 predominantly in the RPE/choroid.
To assess whether Lgr5 is expressed in the mouse retina, we examined the expression of the Lgr5 gene in the retina of Lgr5 EGFP-Ires-CreERT2 knock-in mice, which express EGFP and the inducible Cre recombinase bi-cistronically from the endogenous Lgr5 locus (Barker et al., 2007).
