Mouse responsivity and discrimination threshold data to rat kairomones Dose responsiveness file: Dose responsiveness of mice (n=10) to differing volumes (ul) of rat urine (kairomone) or control (PBS).
In wild-type mice, pressor responsiveness to AngII was augmented with age, such that the pressor response to AngII was similar between aged AT2R-KO and wild-type female mice (31 ± 4 mmHg versus 34 ± 3 mmHg, respectively, on day 14, P = 0.9).
(E ) Slo2.1 KO mice exhibit CQ responsiveness identical to WT mice.
In DES-treated castrated mice, DHT implants restored SV weights to normal levels in αERKO mice but not in WT mice, suggesting full androgen responsiveness in αERKO mice.
In our mouse model, hyper-responsiveness to stressors was associated with psychomotor activity alterations, resembling the restlessness, sleep discontinuity and early awakenings commonly observed in melancholic depression.
In the brain of EAE+ PTx icv mice, anti-Iba1 antibody reacted strongly with amoeboid-shaped cells, corresponding to activated microglia on day 7. Wild type controls manifest ramified or resting microglia; whereas EAE mice manifest intermediate responsiveness and ramification (Fig. 9-C, D, F).
DES Exposed α ERKO male mice retain androgen responsiveness in SV.
(C ) Slo2.2 KO mice exhibit enhanced responsiveness to CQ injection.
Sera were obtained from blood collected by cardiac puncture from mice after airway responsiveness measurements.
KO mice display increased responsiveness to insulin, decreased PPAR-α expression, and altered circadian rhythm of liver genes controlling glucose and fatty acid metabolism.
An alternative explanation for our findings is that chronic hypercalcemia in Casr+/- mice downregulated the responsiveness of calcitonin through indirect effects, such as by downregulation of another calcium sensor that in turn might regulate calcitonin.
