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There is no ortholog of human A2ML1 in mouse, rendering the direct in vivo demonstration of the pathogenicity of anti-A2ML1 antibodies by passive transfer studies impossible.
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The ease to culture, moderately less safety constraints in handling, and above all, hurdle free induction of an anticipated infection in mouse rendered Listeria monocytogenes the rank of a model organism for studying a variety of host immune responses.
Passive anti-viral immunotherapy greatly suppresses the incidence of spontaneous leukemia in AKR mice, rendering the thymus of successfully treated animals devoid of infectious ecotropic retrovirus.
Mutations of the gene Lps selectively impede lipopolysaccharide (LPS) signal transduction in C3H/HeJ and C57BL/10ScCr mice, rendering them resistant to endotoxin yet highly susceptible to Gram-negative infection.
A new DNA vaccine can pump out unprecedented amounts of flu protein into the bloodstream of mice, rendering them resistant to the flu virus.
We used the attenuated HE-ECTV, because Mo-ECTV causes severe liver and spleen destruction in gzmA×B−/− mice, rendering an analysis of splenocytes not feasible [14].
Removal of PMN by a single injection of RB6-8C5 induces a profound immune suppression in C57Bl/6 mice rendering the normally resistant mice highly susceptible to a pulmonary infection with Aspergillus fumigatus (data not shown).
The study found that administering the medical food cocktail for 6 months improved cortical- and hippocampal- dependent learning in the transgenic mice, rendering their performance indistinguishable from non-transgenic controls.
No adverse reaction such as local inflammation at the sites of injection or weight loss was observed in any immunized mice rendering the safety of these adjuvant-free vaccine formulations.
Mannan successfully adjuvanted H1N1 vaccination in mice, rendering otherwise weakly immunogenic doses inductive of strong serum IgG, and IgA in the lung.
Consequently, clearance of vincristine might occur more rapidly in our populations of Mdr1ab DKO and Mdr1ab/Mrp1 TKO mice, rendering them less susceptible to vincristine.
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