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This updated mouse reconstruction was named iSS1393.
The mouse reconstruction was then manually completed and validated.
A previously published mouse reconstruction was expanded by intestinal transport reactions based on literature and was improved by correcting for duplicate or nonfunctional reactions and erroneous GPRs.
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First, we aimed to understand the metabolic differences between human and mouse to ensure that the mouse reconstruction is not merely a modified version of human metabolism.
Analysis of the reactions removed from Recon 1 during the creation of iMM1415 revealed that the greatest absolute number of non-included reactions in the mouse reconstruction were within steroid metabolism (16 out of 46 reactions) and blood group biosynthesis (14 out of 46 reactions).
Metabolic networks have been reconstructed for two further mammals, a central metabolic reconstruction of cattle (Bos taurus) [ 21] and four mouse (Mus musculus) reconstructions [ 22- 25].Twofof these mouse reconstructions were constructed manually [ 24, 25], while the remaining two were generated semi-automatically [ 22, 23].
The initial search for homologous genes indicated that a functional mouse reconstruction could be produced based on Recon 1.
In two more recent studies [ 14, 23] a commercially-available PET/CT device equipped with PSF reconstruction was used to image several mice simultaneously.
The cost of postwar reconstruction was immense.
Reconstruction was a hurricane in North Carolina.
The reconstruction was only restarted in 1995.
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