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However, both the human and mouse proteins show the same specificity and are active ligands for mouse Tyro3 and Mer.
The reason for this difference is not understood, though it is possible that the human and mouse proteins show differences in reactivity to the S830 antibody: however, the ubiquitin immunohistochemistry also shows that intranuclear inclusions are present in the HdhQ150 but not the YAC128 mouse brain at 5 months.
Similar(58)
In the course of our analysis, a similar number (8,522) of unique mouse proteins showed significant similarity to sequences contained in the assembled transcriptome of H. glaberrima.
The analysis of mice proteins showed the same thing.
In both controls and trisomic mice, proteins showing sex differences are diverse in their functional classifications.
Human and mouse PANK2 proteins show an identity of 90%, although the mouse polypeptide does not have an N-terminal extension, which is present in human PANK2.
Human and mouse p53 proteins showed almost identical specificity, consistent with their highest sequence conservation.
Despite the fact that mice deficient in these proteins show enhanced survival in an experimental model of abdominal sepsis, and the observation that blood levels of these proteins are elevated in patients with sepsis 92, there is not yet any significant evidence that they are clinically useful as biomarkers of sepsis.
In control mice, 10 proteins showed sex differences in the hippocampus, all elevated in females (Additional files 3 and 4).
While mice lacking individual Vav family proteins show partial to no defects in T lymphocytes, VavNULL mice show a severe block in T cell development [29], [38], [39], [40], [55].
Finally, when stimulated with H-2Kb-OVA or H-2Kb-Q4R7 peptide-MHC Tetramers, T cells from OT-I Rag2−/− mice expressing LCKS59A proteins showed a higher proliferation than those from OT-I Rag2−/− mice expressing wild-type LCK proteins (Fig 7B).
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