Localised to the nucleus, it is transported to the cytosol and activated by binding two associated proteins STE20-related adaptor (STRAD), a catalytically inactive kinase-like protein, and an armadillo repeat-containing protein named mouse protein 25 (MO25).
To this end, we synthesized and used a chimeric fusion protein, named mouse TPO Receptor-Maltose Binding Protein (mTPOR-MBP), able to inhibit TPO biological activity.
Engineered in lab mice, this gene produced a protein (named OPG) that vastly increased bone strength and thickness-without causing any harmful side effects.
We reported previously a weak similarity to a protein named Fjx1, which is the mouse orthologue of a Drosophila protein named four-jointed [ 8].
Studies in transgenic mice have provided evidence that intracellular accumulation of the mutant misfolded protein, named α1-antitrypsin Z ATZZ), is proteotoxic.
Now, we have engineered a novel Jazz-fusion protein named "Vp16-Jazz" in order to optimize its expression in transgenic mouse skeletal muscle.
Furthermore, some HML-2 loci encode a functional homologue of the HIVRev protein, named Rec, that interacts with PLZF (a protein involved in spermatogenesis in the mouse) and that results in disturbed spermatogenesis in Rec-transgenic mice [ 35, 36].
We have previously shown that the artificial three-zinc finger protein named Jazz fused with the Vp16 activation domain, is able to bind utrophin promoter A and to increase the endogenous level of utrophin in transgenic mice.
A protein named after the Greek goddess who spins life's thread has joined the short list of ways to extend a mouse's natural life span.
Wnt proteins are a family of secreted cysteine-rich glycosylated protein that are named after the Drosophila protein "wingless" and the mouse protein "Int-1" [ 4].
