Sentence examples for mouse prostate is from inspiring English sources

In summary, targeted overexpression of h15-LO-1 (a gene overexpressed in human PCa and HGPIN) to mouse prostate is sufficient to promote epithelial proliferation and mPIN development.

Collectively, the collagenous stroma in the aged mouse prostate is characterized by a disorganized and disrupted collagen matrix.

However, and unlike humans where prostate tumorigenesis likely evolves over decades, disease progression in the constitutively Pten deficient mouse prostate is relatively rapid, culminating in invasive cancer within several weeks post-puberty.

Thus, the unique stromal remodeling and early invasive phenotype resulting from cooperation between AKT1 and MYC in the mouse prostate is associated with an infiltration of T- and B-lymphocytes, as well as macrophages.

Thus, the majority of the glandular-adjacent cellular stroma in the mouse prostate is represented by smooth muscle cells, consistent with prior studies of murine and human prostates [18], [19], [24].

While the mechanism(s) by which MYC regulates Nkx3.1 protein in the mouse prostate is not clear, Ellwood-Yen et al. showed that mouse Nkx3.1 mRNA was reduced by MYC [1], suggesting that the regulation may at least in part be at the level of mRNA.

The gene expression changes measured in the stroma of aged mouse prostate was indicative of a pro-inflammatory environment.

MRI measurements of the mouse prostate are desirable for visualizing the prostate over time with the flexibility of being able to manipulate contrast.

NKX3.1, another homeobox gene involved in the development of mouse prostate, was also highlighted in our studies.

Tgfbr2floxE2/floxE2 and Tgfbr2fspKO mouse prostates were dissected and frozen in liquid nitrogen.

Briefly, thawed cryosections of mouse prostates were placed in the fixative solution for 10 min.