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We performed power calculations on our rat and mouse prostate data versus data of Nagel et al. (1997).
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Prostatic intraepithelial neoplasia development in these mice is restricted to the anterior mouse prostate lobes and is not found in the ventral prostate lobe.
Transgenic adenocarcinoma of the mouse prostate.
We used animals designed to develop this disease, Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice, to investigate the potential role of AHR signaling in prostate cancer development.
Tumor data are triangles, healthy prostate data are diamonds, and muscle are squares.
To further define the role of 15-LO-1 in prostate carcinogenesis, we established a novel GEM model with targeted overexpression of h15-LO-1 in the prostate [human fifteen lipoxygenase-1 in mouse prostate (FLiMP)].
Primary prostate colonies from DsRED transgenic mouse prostate cells were trypsinized and dissociated into single cells.
Study of tumor development in mouse prostate cancer models can be instrumental in understanding human prostate cancer.
RNA from microdissected mouse prostate stroma and epithelium, and human prostate fibroblast (PSC27) were used as template for qRT-PCR.
Similarly, prostate stromal genes show better correlation with prostate data (PU: 0.20/PD: 0.26) than with breast data (PU: 0.00/PD: 0.01) (Figure 1B).
In the present study, we found that the expression of Nrf2 was suppressed in prostate tumor of the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice.
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