Our observations in iASPPΔ8/Δ8 mouse prostate epithelium are in complete agreement with previous findings whereby iASPP inhibits cellular senescence and binds and regulates p63 function in maintaining homeostasis of stratified epithelium in mouse skin and oesophagus.
In contrast to human prostate, which has a complete prostate tissue unit with a continuous basal and luminal layer, the mouse prostate has four major lobe pairs and is further divided into numerous ducts.
New proof that the mouse prostate contains stem cells could aid cancer research.
Wang, X.-D. et al. Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis.
Liang, Z. et al. Plasmid-based Stat3 siRNA delivered by hydroxyapatite nanoparticles suppresses mouse prostate tumour growth in vivo.
Liu, J. et al. Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate.
We used animals designed to develop this disease, Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice, to investigate the potential role of AHR signaling in prostate cancer development.
Transgenic adenocarcinoma of the mouse prostate.
Transgenic mice expressing a subphysiological level of a p53(R172L) minigene (PB-p53(R172L)) in the prostate epithelium were generated and bred to the transgenic adenocarcinoma mouse prostate (TRAMP) model of prostate cancer.
Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model.
