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Unlike the humble mouse, primates are afforded at least some protection under the Animal Welfare Act.
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In comparison with the transcriptional changes found in mice, the effects in primates are generally weaker.
Reports on the immunogenicity of recombinant HCV glycoproteins in mice and non-human primates are variable (Elmowalid et al., 2007; Jeong et al., 2004; Lechmann et al., 2001; Murata et al., 2003; Qiao et al., 2003; Stamataki et al., 2007), with higher titer antibody responses generally observed in mice.
RHOXF1 and RHOXF2 in primates are functionally similar to Rhox5 in mouse.
"Primates are fascinating.
We're primates and most primates are pretty status-oriented.
Delivery of AAV.DYSF.DV via intramuscular and vascular delivery routes in dysferlin deficient mice and nonhuman primates was compared for efficiency and safety.
It provides strong protection in mice and non-human primates, is safe, even in immune compromised animals, and genetically stable after in vitro and in vivo passages.
Moreover, mucus or homogenized gastric tissue of infected mice, pigs or non-human primates was always used as inoculum [15] [22].
Electrophysiology in nonhuman primates is not commonly employed given that mouse models are usually readily available.
All primates were adults.
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