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The average MAF for CD-1 mouse populations was based on the small number of SNPs that overlapped between the two SNP panels after excluding one SNP (rs13480734) because the minor allele was not consistent across CD-1 subpopulations.
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But the boom cycle was followed by one of the smallest acorn crops ever seen, and mouse populations are crashing, he said.
Outbred laboratory mouse populations are widely used in biomedical research.
CD-1 mouse populations are overall genetically less diverse than Swedish, Finnish, or HapMap populations, but they are similarly separated into subpopulations when grouped according to facility of origin.
Helicobacter hepaticus, a bacterium discovered in 1994 and widespread in many experimental mouse populations, is associated with a high incidence of liver tumors in aging mice.
These results are consistent with other data [ 2] suggesting that mouse populations are resistant to secondary invasion by females (mtDNA is a maternally inherited marker).
Thus, our estimates of the recent selective pressures acting on lncRNAs in mouse populations are compatible with their levels of long-term evolutionary conservation.
Samples from two subspecies and 11 distinct wild mouse populations were analyzed to assess patterns of allelic variation of Xpr1 (see Table 1 for sampling locations).
Since the peripheral DN T cells in MRL/lpr mice are B220+ [ 59] and those in IIJ mice are B220- (data not shown), it is unlikely that these mouse populations are identical.
This is in agreement with previous suggestions that house mouse populations are resistant to subsequent invasion by later arrivals [ 3, 4, 6], and provides support for other studies which have assumed that modern house mouse phylogeography reflects ancient events.
Association mapping with outbred mouse populations is similar to human GWA studies in many respects, including the use of high-density SNP genotyping and genome-wide SNP-based association testing.
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