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The CC was initiated to generate a reproducible mouse population with an accumulation of recombination events to facilitate genetic studies [16].
In this respect, the eye GeneNetwork database was evaluated because it includes the largest and most genetically diversity mouse population with >100 strains [ 16].
As a result of selection and likely the occurrence of natural mutation(s) over 25 generations, a mouse population with a high muscular phenotype had been generated.
There was insufficient resolution in the sequence data to identify the source of the Icelandic house mouse population with any precision, as the most common haplotype (U47436) has been found widely in northwestern Europe.
A new outbred mouse population with high genetic diversity will facilitate the identification of genes associated with renal aging by enabling high-resolution genetic mapping while also allowing the control of environmental factors, and by enabling access to renal tissues at specific time points for histology, proteomics, and gene expression.
We then correlated the mLVP volume to inflamed and uninflamed ears in the mutant mouse population with either uni- or bilateral OM and found that the mLVP was significantly smaller in inflamed ears compared with ears without OM, demonstrating a direct correlation between mLVP muscle size and development of the disease (Fig. 8B; Supplementary Material, Table S1).
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Wherry is also cautious, pointing out that, aside from the reproducibility issue, it will also be expensive and time consuming to create and house mouse populations with the desired immune profiles.
Altered patterns of transgene expression within a mouse population and with age can affect results (Lopez et al., 2011).
Nearly half of the DO mouse population rapidly developed morbidity associated with necrosis of lung tissue and granulomas, with neutrophil influx.
Children will undoubtedly be entertained by the book's premise: Skilley, a London alley cat who has no taste for mice, takes up residence at Ye Old Cheshire Cheese and strikes a cheese-for-amnesty deal with the mouse population, led by a literate charmer named Pip.
We have used the largest mammalian genetic model system, the BXD mouse population, to identify candidate genes with sex-specific effects in immune responses to T. muris infection.
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