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Although the method was used to determine percentage mottling, the vast majority of mice were less than 50% "black" and the highest percent mottling reported in a large mouse population was about 80% "black".
The breeding scheme to produce a segregating mouse population was set up to enable both the identification of QTL, as well as to allow for the mapping of a chemically-induced unknown mutation that resulted in a greater amount of wakefulness (referred to as the Sleepless mutation) on a C57BL/6J (backgroundound.
Therefore, it is likely that the higher estimate of marker-explained variance in the mouse population was indeed due to imprinting.
On Cochons Island the mouse population was also inadvertently affected by a rabbit eradication program using poison from 1992 to 1997 [ 24].
The BXH F2 mouse population was constructed from C57BL/6J ApoE null (B6.ApoE-/) and C3H/HeJ ApoE null (C3H.ApoE-/) mice [ 16, 19].
However, even after elimination of the majority of Type II lesions, the variability of the surviving C3HeB/FeJ mouse population was still somewhat higher than that typically observed in BALB/c mice, which only present with Type III lesions.
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Now the field mouse population is expected to crash — about 90 percent have died off in similar glut-dearth acorn sequences in the past.
For the entire mouse population, males and females combined, cancer rates were practically identical across doses; at 0, 500, 2,000, 8,000 and 16,000, rates for the whole mouse population were 61.6%, 61.6%, 60.7%, 54.2% and 61.2%, respectively.
Because distribution of QRS intervals in the Scn5a+/− mouse population is bimodal, we speculate that a compensatory mechanism is active in the mild-phenotype subgroup but inactive in the severe-phenotype subgroup.
Isolating the specific causative regulatory mutations underlying eQTLs that are responsible for variation of gene expression in a segregating mouse population is difficult.
We also found that platelets of a transgenic AD mouse population are generally more susceptible for apoptosis and necrosis compared to human platelets.
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