Sentence examples for mouse phenotype terms from inspiring English sources

The complete list of 5,142 mouse phenotype terms with their corresponding Mammalian PhenoCode designations can be found in Table S5a[ 39].

Our work further confirms the hypothesis of Kuhn et al. (2013), who mapped 116 mouse phenotype terms to drug effect terms and evaluated 398 knockout mice in an effort to identify proteins that underlie particular drug effects.

To test these hypotheses, we first made drug effects and mouse phenotypes comparable by mapping the drug effects described in the SIDER database (Kuhn et al., 2010) with human and mouse phenotype terms, and then integrating human and mouse phenotypes across species (see Section 2).

Similarly, the mouse phenotype term abnormal fibula morphology (MP 0002187) is decomposed into the entity fibula (MA 0001360) and the quality morphology (PATO:0000051) with the qualifier abnormal (PATO:0000460).

Their significant enrichments for the Mouse Phenotype term 'abnormal circadian rhythm' (q = 1.2×10-4) and for Gene Ontology (GO) annotations relating to signalling pathways (q < 0.05; Figure 1B) are consistent with the SCN's role as the master pacemaker.

To describe the biological consequences of the different developmental blocks in more detail, we analyzed the 'Biological Process' GO terms and 'Human and Mouse Phenotypes' terms using ToppCluster.

The DMRs were also associated with mouse phenotype GO terms "cell proliferation" (P = 6.6 × 10−8), "azoospermia" (P = 6.0 × 10−7), and "abnormal sperm number" (P = 1.2 × 10−6) (Fig.  4d; Additional file 4: Table S3).

Similar to human phenotype normalization, we have normalized mouse and rat phenotype terms to EFO and SNOMED-CT.

All phenotypes will be captured using standard annotation and vocabularies [Mouse Phenotype Ontology (MP) terms; see below].

The Mammalian Phenotype Ontology (MP), developed at the Mouse Genome Informatics (MGI, the Mouse Genome Database)— http://www.informatics.jax.org/ with RGD contributing terms, is used for the annotation of rat, human or mouse genes to phenotype terms as applicable.

In total, using the standardised phenotyping protocol, we were able to distinguish 166 different abnormalities, 115 of which could be reasonably described using a set of 109 mouse phenotype (MP) ontology terms (see supplementary material Tables S1, S2).