This would suggest that the defective (compared with mouse) eye phenotype described in this paper is perhaps highly conserved in the Old World moles of genus Talpa.
Using this construct three independent transgenic lines were obtained, hereafter called BCS mice, which all exhibited the phenotype described below.
This effect appears to be significantly stronger than the phenotype described in mice (Adamantidis et al., 2007; Carter et al., 2012), suggesting that zebrafish may be more sensitive to the arousing effect of Hcrt.
Lungs from E17.5 Crem+//−, Crem+/− (Fig. 2D) and Creb1−/−, Crem−/− (Fig. 2E) mice also showed no overt morphological differences to the phenotype described for Creb1−/−, Crem+/+ mice (Fig. 1F).
The reduced cortical area and loss of typical reticular morphology is similar to the phenotype described for the involuted thymus of aged mice [57], [58].
The phenotype described in Figure 3 A and B was the result of systemic RASSF1A knockout in mice.
PhenomeNET enables the direct comparison of phenotypes across multiple species (Hoehndorf et al., 2011b, 2013), including mouse model phenotypes (describing using the MP) and human drug effects (described using the UMLS and mapped to HPO using our approach).
Thus, flox/flox mice show all the major phenotypes described here, including resistance to diet-induced obesity, reduced diet-induced fat accumulation and adipose tissue inflammation, enhanced lipolysis, reduced diet-induced catecholamine resistance and enhanced noradrenergic signaling.
Although the precise mechanism by which Pb inhibits fracture-healing remains a topic for future investigation, the phenotype is very reproducible and is somewhat reminiscent of phenotypes described in other mouse models.
