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The mouse phenotype data were retrieved from Mouse Genome Informatics (MGI) database [43].
ToppGene combines mouse phenotype data with human gene annotations and literature.
This is supported by gene and protein interaction, motif sharing, annotation similarity and mouse phenotype data.
We obtained the human-mouse orthology and mouse phenotype data from Mouse Genome Informatics http://www.informatics.jax.org/[ 17].
We present here a detailed analysis of the most extensive longitudinal mouse phenotype data set published to date.
We downloaded mouse phenotype data from the Mouse Genome Informatics (MGI) database (Blake et al., 2011) on February 14 , 2013
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At the time of writing, 2,358 human genes are associated with Mendelian phenotypes, but more importantly there are 5,492 human genes with no such phenotype associations, where an orthologous mouse or zebrafish gene does have phenotype data (Data obtained by analysing the file HSgenes_crossSpeciesPhenoAnnotation.txt from http://purl.obolibrary.org/obo/hp/uberpheno/).org/obo/hp/uberpheno/
In this paper, we conducted an extensive and careful analysis for the mouse KO phenotype data and corroborated a strong effect of duplicate genes on mouse genetics robustness.
Z. Su et al. performed an extensive analysis of the mouse knockout phenotype data and corroborated a strong effect of duplicate genes on mouse genetics robustness.
The orthologous gene pairs between humans and mice were grouped into essential genes and non-essential genes by inferring the mouse KO phenotype data (Methods).
SNP genotype data from the 76 CCBAF2 mice and phenotype data from 168 non-genotyped CCBAF2 mice were incorporated into the linkage analysis.
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